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Boltz

What Boltz does

Boltz (Boltz PBC) is an AI-for-science company focused on open biomolecular foundation models and production-oriented tooling for drug discovery and protein design. Its models target core bottlenecks in early-stage discovery—predicting biomolecular structures/complexes and estimating binding properties—then packaging those capabilities as both open-source model releases (Boltz-1, Boltz-2, BoltzGen) and as an API and agentic platform (BoltzMol-1, BoltzProt-1, Boltz API, and Boltz Lab) intended to be easier to deploy inside real research workflows. Boltz’s platform approach is oriented around (1) efficient, scalable inference and (2) integrating model calls into agentic or pipeline-style usage so scientists can iterate faster without needing to manage heavy ML infrastructure themselves. In 2026, Boltz positioned this productization effort around a “Boltz Lab” beta and a broader integration push via enterprise interfaces and API endpoints, alongside partnerships with multiple pharma organizations (for example, Pfizer, GSK, and Takeda) to deploy and (where relevant) fine-tune models and workflows on proprietary data.

News

Company record

Jul 02, 2026 · Official · BoltzBoltz Announces Collaboration with GSK to Deploy Biomolecular AI Models for Drug Discovery

Boltz announced a collaboration with GSK to deploy Boltz biomolecular AI models, platform components (Boltz Lab and Boltz API), and research scientists across GSK’s discovery pipeline; Boltz also stated it would work on fine-tuning with GSK proprietary data and that GSK retains full ownership of compounds produced.

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Jun 30, 2026 · Official · BoltzDriving the Boltz API with agents and integration with Claude Science

Boltz described integration/access across Claude products including Claude Science, and shared example workflows showing LLM-driven end-to-end orchestration of Boltz API calls for design and lead-optimization loops.

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Jun 18, 2026 · Official · BoltzBoltz Announces Collaboration with Takeda to Deploy Frontier Biomolecular AI Models Across Takeda's Research Organization

Boltz announced a collaboration with Takeda to deploy Boltz models and platform capabilities (including Boltz Lab and Boltz API access) across Takeda’s research organization, with selected program-level fine-tuning; Takeda retains ownership of compounds generated.

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Jun 16, 2026 · Official · BoltzAnnouncing BoltzMol-1, BoltzProt-1, and the Boltz API

Boltz released BoltzMol-1 and BoltzProt-1 pipelines alongside the Boltz API for running Boltz models efficiently and cheaply at scale; it also described launch partnerships/integrations and provided prospective screening and de-novo design performance framing.

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Jun 16, 2026 · Official · BoltzA note on de novo binder design model evaluation

Boltz published a methods-focused note cautioning that evaluation practices for binder design can inflate apparent hit rates and affinities; it outlined problems with ambiguous binding-assay signals and proposed best practices for reporting screening hits vs confirmed binders.

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Jan 08, 2026 · Official · BoltzBoltz and Pfizer Announce Strategic Collaboration for AI Drug Discovery

Boltz announced a strategic collaboration with Pfizer to refine Boltz foundation models on Pfizer’s historical data and deploy Boltz’s platform/workflows for small-molecule and biologics design; it stated Pfizer retains full ownership of compounds discovered or developed.

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Jan 08, 2026 · Official · BoltzAnnouncing Boltz Lab and our first agents

Boltz announced Boltz Lab beta and released its first agents for small-molecule hit discovery and protein de-novo design, describing the agent architecture (e.g., an affinity-model-driven loop for small molecules and an adaptation over BoltzGen for protein binder design) and early experimental validation framing.

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Jan 08, 2026 · Official · BoltzAnnouncing Boltz: A Public Benefit Corporation for AI-Driven Drug Discovery

Boltz introduced Boltz PBC and described the company’s shift toward building durable products around open biomolecular models, alongside the launch of Boltz Lab and the $28M seed round; it also announced a multi-year Pfizer partnership.

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Show 3 earlier updates
Oct 26, 2025 · Official · BoltzBoltzGen: Open-Source Generative Model for Universal Binder Design

Boltz announced BoltzGen, an all-atom generative diffusion model for designing binders across protein/peptide modalities to arbitrary biomolecular targets, with a unified design and structure prediction approach and MIT-licensed open source release.

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Jun 06, 2025 · Official · BoltzIntroducing Boltz-2: Toward Accurate and Efficient Binding Affinity Prediction

Boltz announced Boltz-2, describing a biomolecular foundation model that jointly predicts complex structures and binding affinities, targeting accuracy comparable to physics-based free-energy perturbation methods while running substantially faster; it was released under an MIT license.

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Nov 16, 2024 · Official · BoltzIntroducing Boltz-1: Democratizing Biomolecular Interaction Modeling

Boltz announced the release of Boltz-1, an open-source model aimed at approaching AlphaFold3-level accuracy for 3D structure prediction of biomolecular complexes, and released code/weights/training data under an MIT license.

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Source map · 2 recurring channels · 65 references
BoltzOfficial Site · monitor↗MTS Frontier / Control RoomCurated Feed · monitor↗api.boltz.bioOfficial Reference · reference↗Official company sourceOfficial Reference · reference↗sec.govRegulatory · reference↗23290841.fs1.hubspotusercontent-na1.netReporting · reference↗apis.ioReporting · reference↗apollo-v2-nu.vercel.appReporting · reference↗app.dealroom.coReporting · reference↗arxiv.orgReporting · reference↗axios.comReporting · reference↗biobriefs.comReporting · reference↗bioutah.orgReporting · reference↗bold-awards.comReporting · reference↗builtin.comReporting · reference↗bzfd.comReporting · reference↗cambridge.orgReporting · reference↗cbinsights.comReporting · reference↗chemrxiv.orgReporting · reference↗congress.govReporting · reference↗crunchbase.comReporting · reference↗cvca.caReporting · reference↗d18rn0p25nwr6d.cloudfront.netReporting · reference↗dealroom.coReporting · reference↗discover.pbc.govReporting · reference↗en.wikipedia.orgReporting · reference↗f4.fundReporting · reference↗find-and-update.company-information.service.gov.ukReporting · reference↗firstwordpharma.comReporting · reference↗gem.comReporting · reference↗genengnews.comReporting · reference↗github.comReporting · reference↗govinfo.govReporting · reference↗ictc-ctic.caReporting · reference↗intuitionlabs.aiReporting · reference↗investors.boltbio.comReporting · reference↗ir.biote.comReporting · reference↗ir.genfit.comReporting · reference↗ir.recursion.comReporting · reference↗jeremywohlwend.comReporting · reference↗labscompanies.comReporting · reference↗latestrounds.comReporting · reference↗linkedin.comReporting · reference↗milled.comReporting · reference↗netzeroinsights.comReporting · reference↗nordic9.comReporting · reference↗note.comReporting · reference↗openreview.netReporting · reference↗parkplanning.nps.govReporting · reference↗pbc.gov.cnReporting · reference↗pharmatimes.comReporting · reference↗pmc.ncbi.nlm.nih.govReporting · reference↗preqin.comReporting · reference↗prnewswire.comReporting · reference↗provath.comReporting · reference↗publications.jrc.ec.europa.euReporting · reference↗reader.emagazines.comReporting · reference↗reddit.comReporting · reference↗startupintros.comReporting · reference↗techmeme.comReporting · reference↗theventurecodex.comReporting · reference↗tr.linkedin.comReporting · reference↗trueup.ioReporting · reference↗uk.linkedin.comReporting · reference↗vcbacked.coReporting · reference↗venturecapitaltracker.comReporting · reference↗wsj.comReporting · reference↗

Still resolving: Newsroom · Official X

What it builds

Boltz API

Boltz API provides production-oriented endpoints to run Boltz models (including structure and binding prediction plus small-molecule and protein design workflows) via API/SDKs, including first-party integration support for Claude Code and support for additional agent/CLI ecosystems.

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Boltz Lab

Boltz Lab is a platform interface intended to deliver agentic small-molecule hit discovery and de-novo protein design workflows with compute-efficient inference, collaborative interfaces, and explicit security/IP terms (users own their outputs; Boltz does not train on customer data).

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Boltz-1

Boltz-1 is an open-source biomolecular interaction foundation model for predicting 3D structures of biomolecular complexes, released under an MIT license with training/inference code and weights.

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Boltz-2

Boltz-2 is an open-source biomolecular foundation model that jointly models complex structures and binding affinity prediction, designed to approach the accuracy of physics-based free-energy perturbation while running substantially faster than those methods.

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BoltzGen

BoltzGen is an open-source, all-atom generative diffusion model for universal binder design that unifies design and structure prediction and includes a design specification language to steer generation toward constraints.

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BoltzMol-1

BoltzMol-1 is Boltz’s small-molecule hit-discovery pipeline, positioned around experimentally validated prospective screening results and tied to synthesizable make-on-demand / purchasable in-stock catalog workflows.

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BoltzProt-1

BoltzProt-1 is Boltz’s protein design pipeline for generating binders (including nanobody-oriented workflows) with a specific emphasis on protein-protein interaction/affinity scoring to improve hit prioritization beyond structure-confidence heuristics.

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Key metrics

Milestones & partnerships

Jul 02, 2026
GSK deployment collaboration

Boltz announced deployment collaboration with GSK across its discovery pipeline, with access to Boltz models and platform (Boltz Lab and Boltz API) plus fine-tuning on proprietary data.

GSK
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Jun 30, 2026
Claude Science integration and agentic API examples

Boltz described integration/access across Claude products, including Claude Science, with examples of agentic orchestration of Boltz API calls end-to-end.

Anthropic
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Jun 18, 2026
Takeda deployment collaboration

Boltz announced deployment collaboration with Takeda to provide scientists program-level and organization-wide access to Boltz models and platform interfaces/APIs.

Takeda
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Jun 16, 2026
Launch of BoltzMol-1, BoltzProt-1, and Boltz API

Boltz expanded the Boltz model family with two experimentally validated pipelines (BoltzMol-1 and BoltzProt-1) and introduced the Boltz API for production-scale execution of Boltz models with SDKs and agent integrations.

Benchling · Phylo · Amazon Bio Discovery · Rowan · Tamarind · Kiin Bio · Pauling.ai · Mirror Physics · Cultivarium
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Jan 08, 2026
Boltz PBC + Boltz Lab beta launch

Boltz announced Boltz PBC as a public-benefit corporation and released Boltz Lab in beta with first agents for small-molecule hit discovery and de-novo protein design.

Pfizer (partnership announced same date)
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Jan 08, 2026
Boltz Lab published first agent workflows

Boltz described the first Boltz Lab agents, including experimental validation framing for a small-molecule agent on TYK2 and an enrichment approach for a protein de-novo binder design agent.

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Jan 08, 2026
Pfizer collaboration for model refinement and deployment

Boltz announced a collaboration with Pfizer to refine foundation models on Pfizer historical data and deploy the Boltz platform/workflows for discovery.

Pfizer
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